Hesperetin: An inhibitor of the transforming growth factor-β (TGF-β) signaling pathway
نویسندگان
چکیده
منابع مشابه
Effect of Transforming Growth Factor-β (TGF-β) on proliferation of gastric epithelial cells in culture
Objective: Helicobacter pylori has a well-established role in the development of gastric cancer. In vitro studies reveal increased proliferation of the gastric mucosa in the presence of H. pylori infection. It has been also shown that production of some cytokines, such as interleukin-1 beta (IL-1b) is in...
متن کاملAn engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling.
The transforming growth factor β isoforms, TGF-β1, -β2, and -β3, are small secreted homodimeric signaling proteins with essential roles in regulating the adaptive immune system and maintaining the extracellular matrix. However, dysregulation of the TGF-β pathway is responsible for promoting the progression of several human diseases, including cancer and fibrosis. Despite the known importance of...
متن کاملSuppression of Latent Transforming Growth Factor (TGF)-β1 Restores Growth Inhibitory TGF-β Signaling through microRNAs
Cancer cells secreting excess latent TGF-β are often resistant to TGF-β induced growth inhibition. We observed that RNAi against TGF-β1 led to apoptotic death in such cell lines with features that were, paradoxically, reminiscent of TGF-β signaling activity and that included transiently enhanced SMAD2 and AKT phosphorylation. A comprehensive search in Hela cells for potential microRNA drivers o...
متن کاملGremlin Regulates Podocyte Apoptosis via Transforming Growth Factor-β (TGF-β) Pathway in Diabetic Nephropathy
BACKGROUND Gremlin has been reported to be up-regulated in glomerular mesangial cells in diabetic nephropathy (DN). However, the regulation of gremlin in podocytes is still rarely reported. This study aimed to investigate the underlying mechanisms by which gremlin mediates the pathogenesis of DN via transforming growth factor-β (TGF-β) signaling pathways. MATERIAL AND METHODS Lentiviral and RNA...
متن کاملTransforming Growth Factor-β Signaling by Decorin
3 Chen Zhang, Chek Kun Tan, Craig McFarlane, Mridula Sharma, Nguan Soon Tan*, Ravi 4 Kambadur,*# 5 1. School of Biological Sciences, Nanyang Technological University, Singapore 637551. 6 2 Singapore Institute for Clinical Sciences, A*STAR, 30 Medical Centre Drive, National 7 University of Singapore, Singapore 8 3 Department of Biochemistry, YLL School of Medicine, National University of 9 Singa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2012
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2012.10.028